THE ENDOCANNABINOID SYSTEM and VIRUSES 🦠
Exogenous cannabinoids or receptor antagonists may influence many cellular and systemic host responses.
The anti-inflammatory activity of cannabinoids may compromise host inflammatory responses to acute viral infections, but may be beneficial in persistent infections.
In neurons, where innate antiviral/pro-resolution responses include the activation of NOS-1, inhibition of Ca2+ activity by cannabinoids, increased viral replication and disease.
Cannabinoids may act either through the CB1 or the CB2 receptor, which are found on distinct cell types.
The CB1 receptor is found on neurons as well as some astrocytes and skeletal muscle cells; neurons are frequently the target of viral infection.
Engagement of the CB1 receptor by its endogenous or exogenous agonists may inhibit the release of Ca2+ from intracellular or extracellular stores.
Since many important intracellular proteins are Ca2+-dependent for activation, signal transduction through the CB1 receptor may impair these secondary pathways and have a profound influence on the ability of viruses to replicate in neurons.
In contrast, the response of cells expressing the CB2 receptor may influence not only the responses in that cell, but may alter the course of the host innate and adaptive immune response to the pathogen, suppressing inflammation and the development of virus-specific cellular and humoral responses.
The outcome on the viral infection will depend on whether inflammation is beneficial or pathogenic in the specific case.
More on the subject 🧐
https://www.blaqsbi.com/j89-Post-Chemo-Kills-Healthy-Cells-But-THC-Kills-Cancer
#endocannabinoid #virus #cancer #cannabis
Exogenous cannabinoids or receptor antagonists may influence many cellular and systemic host responses.
The anti-inflammatory activity of cannabinoids may compromise host inflammatory responses to acute viral infections, but may be beneficial in persistent infections.
In neurons, where innate antiviral/pro-resolution responses include the activation of NOS-1, inhibition of Ca2+ activity by cannabinoids, increased viral replication and disease.
Cannabinoids may act either through the CB1 or the CB2 receptor, which are found on distinct cell types.
The CB1 receptor is found on neurons as well as some astrocytes and skeletal muscle cells; neurons are frequently the target of viral infection.
Engagement of the CB1 receptor by its endogenous or exogenous agonists may inhibit the release of Ca2+ from intracellular or extracellular stores.
Since many important intracellular proteins are Ca2+-dependent for activation, signal transduction through the CB1 receptor may impair these secondary pathways and have a profound influence on the ability of viruses to replicate in neurons.
In contrast, the response of cells expressing the CB2 receptor may influence not only the responses in that cell, but may alter the course of the host innate and adaptive immune response to the pathogen, suppressing inflammation and the development of virus-specific cellular and humoral responses.
The outcome on the viral infection will depend on whether inflammation is beneficial or pathogenic in the specific case.
More on the subject 🧐
https://www.blaqsbi.com/j89-Post-Chemo-Kills-Healthy-Cells-But-THC-Kills-Cancer
#endocannabinoid #virus #cancer #cannabis
